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KMID : 0368820180570030261
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Journal of the Korean Neuropsychiatr Association
2018 Volume.57 No. 3 p.261 ~ p.265
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Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease
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Jeong Hee-Jeong
Lee Young-Min
Park Je-Min
Lee Byung-Dae
Moon Eun-Soo
Kim Soo-Yeon
Lee Kang-Youn
Kim Ji-Hoon
Chung Young-In
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Abstract
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Objectives: This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and those without psychosis (AD?P).
Methods: Overall, 31 AD+P patients and 29 AD?P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. AD?P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD?P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume.
Results: The hippocampal volume in AD+P was smaller than that in AD?P.
Conclusion: These findings suggest that AD+P is associated with a reduced hippocampal volume.
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KEYWORD
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Alzheimer's disease, Psychotic symptoms, Medial temporal lobe, Hippocampus
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